At AgeCurve we specialise in delivering direct-to-consumer personal proteomics results to provide deep aging profiles to end users by measuring proteins which contribute to several hallmark aging processes. Using non-invasive salivary collection as our source we can also measure constituents of the oral microbiome; bacteria that inhabit the oral cavity. The oral microbiome may include viruses and fungi too. The human oral holobiome consists of the human host cells their unique molecules and new or permanent guest bacteria, viruses and fungi in the saliva and oral cavity.
We have developed systems for measuring important elements of the holobiome using mass spectrometry proteomics, an unbiased and high-throughput platform that has been thoroughly validated many times over in the last decade for drug discovery and pharmokinetics. Proteins are broken down into peptide sequences, consisting of tens of amino acids. Mass spectrometry measures peptide intensities and sequences these peptide components. Doing so it avoids the pitfalls of other type of measurements where there is a clear and present danger of cross-reactivity yielding false positives, which are hard to control. Our mature bioinformatics platform infers back proteins present in the sample in a reliable and reproduceable way.
We are now working on a so-called targeted proteomics assay that can be quickly developed to measure specific proteins, up to several hundreds at a time to target components of the human holobiome specific to COVID-19 infection. The components and targets of such an assay include:
- Accurately detect presence of COVID-19 proteins in saliva by measuring peptide ions distinct to the COVID-19 proteins.
- Measure proteins providing information about different biological aging processes from our experience in deep age profiling, which potentially indicate accelerated aging status and thereby can inform of risk of disease severity. For instance, by measuring immunosenescence and inflammatory indicators.
- Detect common viruses causing cold and flu-like symptoms to diagnose the kind of infection to inform treatment options.
- Detect strong adaptive immunity signals present in the saliva.
- Detect abundant oral bacteria, changes in levels of the bacteria due to a COVID-19 co-infection and might actually provide hints to infer back the type of viruses the individual has been exposed to in the past. These holobiome changes can potentially be used to detect changes due to recovery from COVID-19 infection, so can be used to confirm serological tests showing virus specific antibodies. This is the most speculative part of the proposal and requires more extensive research.
We need samples from individuals who tested positively for COVID19, please email us at firstname.lastname@example.org in case you have relevant information.
Keep safe and use human ingenuity and flexibility to control the situation,