Sampling from biological aging definitions: ‘Ageotype’ paper, 2020

Ahead of our Towards a consensus definition of biological aging workshop, happening on the 23rd of April in Cambridge, we start a blog series featuring different definitions from the literature and from researchers around.

These definitions will show important elements of the concept while also demonstrating how highly idiosyncratic these definitions are. Thereby supporting the need to come up with a consensus definition based on consensus knowledge.

First definition attempt is from the closed access Nature Medicine paper by Ahadi et al, called Personal aging markers and ageotypes revealed by deep longitudinal profiling. We have highlighted this study in Preliminary study gives hints at different individual aging trajectories. This is the first sentence of the body of the paper and it is referring to 5 more papers.

Aging is a universal process of physiological and molecular changes that are strongly associated with susceptibility to disease and ultimately death.

Commentary: definition attempt consists of 2 main parts and 5 propositions in total:

1/A: aging is a universal process.

1/B: aging is a universal process of two kinds of changes: i., molecular and ii., physiological.

2. association of the aging process with 2 events/changes: i., susceptibility to disease and ii., death.