Three links in aging and longevity

Starting a new series on the blog, sharing 3 interesting links in the field of healthspan extension and aging in general.

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

Emerging findings are revealing mechanisms by which sedentary overindulgent lifestyles accelerate brain aging, whereas lifestyles that include intermittent bioenergetic challenges (exercise, fasting, and intellectual challenges) foster healthy brain aging. Here we provide an overview of the cellular and molecular biology of brain aging, how those processes interface with disease-specific neurodegenerative pathways, and how metabolic states influence brain health.

The longevity dividend: how ageing populations could boost economic productivity

The longevity dividend, like most economic benefits, is attainable but needs to be worked for. Mobilising older workers’ skills, expanding labour forces and fostering intergenerational solidarity will mean that rising life expectancy can be both socially and economically good.

To Heal Some Wounds, Adult Cells Turn More Fetal

But new results suggest that that plasticity may go even deeper than scientists have thought. Three research teams have observed that during tissue regeneration, the typical solutions offered by adult stem cells (and the de-differentiated cells resembling them) aren’t enough. Instead, the cells of the damaged tissue turn the clock back all the way to a more fetal state, tapping into the proliferative power that once characterized development — and a program thought to have long gone silent.