Gen P Molecular Stories: proteome maintenance, ubiquitin

 

Molecular stories are an important feature for Gen P users and we are in the middle of implementing them. Last time we have talked about adaptive immunity where we have consistent quantitative output on some of the immunoglobulin protein players to make a molecular story about this important protein subsystem that is the prime line of defence against pathogens.

The next story is about proteome maintenance, the protein machinery that helps identify and degrade misfolded or damaged proteins or unwanted protein aggregates. This is also called proteostasis, which is the combination of protein and homeostasis. Maintaining proteostasis and thereby normal protein turnover is crucial for the healthy functioning of normal cells. Impairment of this system with increasing age  is well documented and this general decline is considered to contribute to the aging process.

The ubiquitin-proteasome system is one of  the dominant ways to maintain cellular quality control. Throughout the process ubiquitin proteins tag misfolded or damaged proteins that are then transferred onto the proteasome where they are degraded by protein digesting enzymes, see schematic below.

ubi_proteasome-001

One the table below there are some ubiquitin variants that were detected in ALL of our human saliva samples during the ongoing Private Beta. While many other proteins might be used in our molecular story later, these couple give us a confident signal to get started and report it back to our Gen P Users.

ubiquitin-001Would you like to know how abundantly your proteostasis system is present in you and how does that compare to other users in different age clusters? You can participate in our Private Beta now, send and email to privatebeta@agecurve.co.uk.