Gen P Molecular Stories: adaptive immunity

 

One of Gen P‘s crucial features are going to be different molecular stories custom-made for individual users based on the particular protein abundance values measured. These proteins might be human host proteins but can also come from the bacteria that inhabit the human saliva. We are going to have stories using both types of proteins or can just use the actual bacterial species and particular composition of the oral microbiome. As the focus of AgeCurve is on providing our end users with an understanding on their age trajectories the majority of these stories will focus on individual human proteins and bigger functional units of groups of proteins. These groups can consist of tens, hundreds of proteins. Today we are going to talk about our story featuring adaptive immunity. But first … some basics.

The nature and scope of these stories will be limited by the source of these proteins, human saliva. Saliva is a bodily fluid secreted by the salivary glands in the mouth and it can contain many types of different cells and hence many types of expressed and secreted proteins. A big ratio of human salivary cells are white blood cells (or leukocytes) that are the main actors of the human immune system. Unsurprisingly, human saliva provides a good molecular window on immune system activities. Unsurprisingly, because the mouth is continuously exposed to food, infectious agents and the inhabiting oral microbiome. One particular class of white blood cells are lymphocytes and so called B cells form one subclass of these lymphocytes. B cells are crucial in the so called adaptive immune response as they generated antibodies, also known as immunoglobulins (Ig-s). Antibodies help recognise bacteria and viruses by binding to particular molecules (called antigens) originated from these potentially harmful units. Antibodies can be secreted into the intercellular space by B cells called plasma cells or they can be present in the surface of B cells as B-cell receptors.

Most importantly, immunoglobulins are proteins and hence can be detected with the Gen P kit using mass spectrometry proteomics. According to our current Private Beta results many immunoglobulins are consistently detected so we can turn these abundance patterns into one of our earliest molecular stories. In the table below you can read the description of some of the immunoglobulin components that we might use for generating the custom-made story for you using the user’s own abundance values.

ig_score_components-001

Remember that Gen P provides relative abundance measures and strictly does not provide any diagnostic type of information. Instead the user can form a picture of the overall performance of the selected proteins in the context of other users. Adaptive immune responses are very common, day-to-day activities during the life of healthy people. The adaptive immune system and its protein components are changing with age. Our aim is to provide age-sensitive information on user’s adaptive immunity with this molecular story and possibly track age related changes throughout multiple time points. But users only will be able to do this if they start to generate those molecular age profiles now provided only by Gen P currently. For instance, a healthy 45 year old preferably wants to know her profile while being 45 year old and then accumulate this valuable business intelligence in subsequent years. You can be a Private User and order a Gen P kit today, please email privatebeta@agecurve.co.uk to investigate further steps. Eligibility is limited to UK residents over 18 years of age.